Study shows nanofiber scaffolds could treat lymphedema by rerouting lymphatic system around blockages _ news center _ stanford medicine

Researchers at the School of Medicine have developed a possible treatment for lymphedema, the severe swelling of an arm or leg that can occur when the lymph system is blocked. Noodles and company 120th Using scaffolding composed of specially patterned collagen nanofibers, the researchers coaxed lymph vessels to grow around lymph blockages.

“We were able to take a cue from nature about what molecules spur vessel growth, but also think outside the box and use this nanoscale scaffolding to bridge the blockages,” said Ngan Huang, PhD, assistant professor of cardiothoracic surgery and a co-senior author of the study. Noodles and company stock “I think combining the two was really key.” A disease without a cure

The lymphatic system is responsible for draining fluids from the body’s tissues and filtering this lymph fluid.


Food noodles When a lymphatic vessel is blocked, as is the case in lymphedema, fluid can get backed up into a limb, causing painful swelling.

In developed countries including the United States, lymphedema is most often seen in cancer patients whose lymph nodes are affected by their cancer. Noodles and company indonesian peanut saute But infections and genetic conditions can also cause lymph blockages. Noodles and company salads In some cases, the underlying cause of the disease — such as an infection — can be treated. Noodles and company vernon hills But for many, physical therapy, massage and compression garments are the only options to treat the disease and provide just temporary relief.

“Lymphedema is a chronic, debilitating disease with profound functional and psychosocial implications,” said Stanley Rockson, MD, the Allan and Tina Neill Professor in Lymphatic Research and Medicine at Stanford and a co-senior author of the paper. Hours for noodles and company “Current treatments are extremely limited. Noodles n company While transplantation of healthy lymph nodes represents a theoretically viable treatment option for cancer survivors and others, the success rate of these procedures has been disappointing.”

Huang’s lab, in collaboration with the Union City, California-based company Fibralign, has been studying how nanofibers of collagen can be used in medicine. Noodles and company 29th street Collagen, the most abundant protein in the human body, acts as a structural support in a variety of tissues. Noodles and company jacksonville The scientists have designed nanofibers, dubbed “BioBridge,” that mimic collagen’s different arrangements.

“The unique feature about the BioBridge scaffolds is that they’re not just noodles on a nanoscale,” said Huang. Noodles and company stapleton “They have patterning that’s physiologically relevant.” The scaffolds used in the recent work, she said, look like braided noodles, and mimic how collagen is naturally arranged in some connective tissues in the body. Noodles and company denver The threadlike fibers are each about a third of a millimeter wide.

Previously, Huang’s group has studied how the BioBridge nanofibers can be used to guide new blood vessels. When does noodles and company close As new cells that make up the vessels grow, they align themselves along the nanofibers. Noodles and company york pa But lymph vessels, at a molecular level, are similar to blood vessels. Noodles and company minneapolis So Huang and her collaborators wondered whether the fibers could also be used to coax and direct new lymph vessel growth as well. Noodles and company menu gluten free Bridging lymph blockages

The scientists coated stretches of the BioBridge nanofibers with fragments of lymph nodes, since the nodes are known to produce molecules that stimulate new lymph vessel growth. Noodles and companh Then, they surgically implanted the fibers around lymph blockages in pigs with lymphedema, building a stretch of fibers that bypassed each blockage like a bridge. Noodles and company menu pdf After three months, the eight pigs that had received BioBridge scaffolding had 27 lymphatic collector vessels per square millimeter in the area around the implant, significantly more than the 1 lymphatic collector per square millimeter seen in control animals. Food with noodles Moreover, animals with the nanofibers had reduced fluid buildup in their limb affected by lymphedema.

“The sample size wasn’t as good as we would eventually like, but we followed these animals for a total of six months and got a lot of safety data,” said Huang. Noodles and company yorktown “There weren’t any adverse events.”

So far, the BioBridge approach has only been tested in pigs. Where are noodles from But Fibralign has a small clinical trial planned in Latin America, and Rockson is putting together a Stanford-based study to test the treatment in breast cancer patients with lymphedema.

The lead author of the paper is Catarina Hadamitzky, MD, of the Helios Clinic in Hildesheim Germany. Noodles plus menu The other co-senior author is John Cooke, MD, PhD, formerly a professor of medicine at Stanford who is now at the Houston Methodist Research Institute in Texas.

Other Stanford co-authors are former postdoctoral scholar Magdalena Bazalova-Carter, PhD; postdoctoral scholar Luqia Hou, PhD; research associate Yuka Matsuura; assistant professor of medicine Rajesh Dash, MD, PhD; and associate professor of medicine Phillip Yang, MD. Noodles and company boise They collaborated with researchers from the University of Victoria, Veterans Affairs Palo Alto Health Care System, Surpass Inc., IntraOp Medical Corp. Noodles and company yelp and Fibralign Corp., which produces the aligned nanofibrillar collagen scaffolds used in this study. Noodles menu calories Hadamitzky and Cooke have received subscription rights in Fibralign.